Overview

  • Product name
    10058-F4
  • Description
    Cell-permeable c-Myc-Max dimerization inhibitor
  • Biological description
    Cell-permeable c-Myc-Max dimerization inhibitor. Downregulates c-Myc expression and upregulates CDK inhibitors, p21 and p27. Inhibits proliferation. Induces apoptosis and cell cycle arrest in G0/G1 phase. Shows antitumor effects in vivo.
  • Purity
    > 99%

Properties

  • Chemical name
    5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone
  • Molecular weight
    249.35
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C12H11NOS2
  • CAS Number
    403811-55-2
  • PubChem identifier
    1271002
  • Storage instructions
    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in ethanol to 25 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CCC1=CC=C(C=C1)C=C2C(=O)NC(=S)S2
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Guo J  et al. Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice. Cancer Chemother Pharmacol 63:615-25 (2009). Read more (PubMed: 18509642) »
  • Lin CP  et al. Small-molecule c-Myc inhibitor, 10058-F4, inhibits proliferation, downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular carcinoma cells. Anticancer Drugs 18:161-70 (2007). Read more (PubMed: 17159602) »
  • Huang MJ  et al. A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia. Exp Hematol 34:1480-9 (2006). Read more (PubMed: 17046567) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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