10,11-Dehydrocurvularin, antibiotic and antimitotic agent (ab144855)

Overview

  • Product name

    10,11-Dehydrocurvularin, antibiotic and antimitotic agent
  • Description

    Antibiotic and antimitotic agent. Heat shock response activator.
  • Biological description

    Antibiotic. Antifungal. Nematicidal. Phytotoxic. TGF-beta signaling inhibitor. Anticancer compound. Strong activator of the heat shock response. Inhibits the appressorium formation of M. grisea.
  • Purity

    > 95%
  • CAS Number

    1095588-70-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Rudolph K  et al. Inhibition of TGF-ß signaling by the fungal lactones (S)-curvularin, dehydrocurvularin, oxacyclododecindione and galiellalactone. Cytokine 61:285-96 (2013). Read more (PubMed: 23134667) »
  • Xu Y  et al. Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreus. Appl Environ Microbiol 79:2038-47 (2013). Read more (PubMed: 23335766) »
  • Santagata S  et al. Using the heat-shock response to discover anticancer compounds that target protein homeostasis. ACS Chem Biol 7:340-9 (2012). Read more (PubMed: 22050377) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab144855.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up