Overview

  • Product name
    10Z-Hymenialdisine, pan kinase inhibitor
  • Description
    Potent pan kinase inhibitor
  • Biological description
    Potent pan kinase inhibitor (IC50 values are 6, 10, 22, 28, 35, 40, 70, 80, 100, 470, 500, 600, 700 and 700 nM for MEK1, GSK-3β, Cdk1/cyclin B, Cdk5/p25, CK1, Cdk2/cyclin A, Cdk2/cyclin E, ASK-γ, Cdk3/cyclin E, Erk1, PKCγ, Cdk4/cyclin D1, Cdk6/cyclin D2 and PKCα respectively). Inhibits NF-κB and IL-8 production (IC50 values are 1-2 and 0.34-0.48 μM respectively, U937 cells). Inhibits MARK2.
  • Purity
    > 97%

Properties

  • Chemical name
    (4Z)-4-(2-Amino-4-oxo-1H-imidazol-5-ylidene)-2-bromo-1,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one
  • Molecular weight
    324.13
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C11H10BrN5O2
  • CAS Number
    82005-12-7
  • PubChem identifier
    3035462
  • Storage instructions
    Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overview
    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C\1CNC(=O)C2=C(/C1=C\3/C(=O)N=C(N3)N)C=C(N2)Br
  • Source

    Axinella carteri

  • Research areas

References

This product has been referenced in:
  • Tasdemir D  et al. Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). J Med Chem 45:529-32 (2002). Read more (PubMed: 11784156) »
  • Biernat J  et al. Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity. Mol Biol Cell 13:4013-28 (2002). Read more (PubMed: 12429843) »
  • Breton JJ & Chabot-Fletcher MC The natural product hymenialdisine inhibits interleukin-8 production in U937 cells by inhibition of nuclear factor-kappaB. J Pharmacol Exp Ther 282:459-66 (1997). Read more (PubMed: 9223588) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab144275.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

Sign up