1,1-Dimethyl-4-phenylpiperazinium iodide (DMPP), nAChR agonist (ab145562)

Overview

  • Product name

    1,1-Dimethyl-4-phenylpiperazinium iodide (DMPP), nAChR agonist
  • Description

    nAChR agonist
  • Biological description

    nAChR agonist (IC50 = 0.77 μM, α4 receptor). Weak, partial α7 agonist. Shows positive inotropic effects. Shows ganglionic stimulant and anti-inflammatory effects in vivo.
  • Purity

    > 98%
  • CAS Number

    54-77-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1,1-Dimethyl-4-phenylpiperazinium iodide
  • Molecular weight

    318.20
  • Molecular formula

    C12H19IN2
  • PubChem identifier

    5911
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[N+]1(CCN(CC1)C2=CC=CC=C2)C.[I-]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Murad HA & Hasanin AH The anti-inflammatory effects of 1,1 dimethyl-4-phenylpiperazinium (DMPP) compared to dexamethasone in a guinea pig model of ovalbumin induced asthma. Eur Rev Med Pharmacol Sci 18:2228-36 (2014). Read more (PubMed: 25070830) »
  • Ochi K  et al. A ganglionic stimulant, 1,1-dimethyl-4-phenylpiperazinium, caused both cholinergic and adrenergic responses in the isolated mouse atrium. Eur J Pharmacol 704:7-14 (2013). Read more (PubMed: 23461847) »
  • Kizawa Y & Takayanagi I Nicotinic stimulant, DMPP(1,1-dimethyl-4-phenylpiperazinium iodide) on the isolated bronchial smooth muscle preparation of guinea-pig. Gen Pharmacol 15:149-50 (1984). Read more (PubMed: 6714642) »

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