Overview

  • Product name
    1,10-Phenanthroline, Metalloprotease inhibitor
  • Description
    Membrane permeable chelating agent. Metalloprotease inhibitor.
  • Biological description
    Membrane permeable chelating agent. Metalloprotease inhibitor. Chelates intracellular heavy metals including zinc, copper and iron. Binds DNA and modulates multiple signaling pathways in vitro and in vivo.
  • Purity
    > 99%
  • CAS Number
    66-71-7
  • Chemical structure
    Chemical Structure

Properties

References

This product has been referenced in:
  • Mudasir  et al. DNA binding of iron(II) complexes with 1,10-phenanthroline and 4,7-diphenyl-1,10-phenanthroline: salt effect, ligand substituent effect, base pair specificity and binding strength. J Inorg Biochem 94:263-71 (2003). Read more (PubMed: 12628706) »
  • Watanabe K  et al. 1,10-Phenanthroline phosphorylates (activates) MAP kinase in Xenopus oocytes. Cell Signal 15:1139-47 (2003). Read more (PubMed: 14575869) »
  • Bolzán AD  et al. The effect of 1,10-phenanthroline on the chromosome damage and sister-chromatid exchanges induced by streptozotocin in mammalian and insect cells. Mutat Res 447:221-6 (2000). Read more (PubMed: 10751605) »
  • Day TA & Chen GZ The metalloprotease inhibitor 1,10-phenanthroline affects Schistosoma mansoni motor activity, egg laying and viability. Parasitology 116 ( Pt 4):319-25 (1998). Read more (PubMed: 9585934) »

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