1,3-Dipropyl-8-p-sulfophenylxanthine, Adenosine receptor antagonist (ab144757)

Overview

  • Product name

    1,3-Dipropyl-8-p-sulfophenylxanthine, Adenosine receptor antagonist
  • Description

    Water soluble adenosine receptor antagonist with slight selectivity for A1 receptors. Ecto-phosphodiesterase inhibitor.
  • Alternative names

    • 1,3-Dipropyl-8-(p-sulfophenyl)xanthine
    • 4-(2,3,6,7-Tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)benzenesulfonic Acid
  • Biological description

    Water soluble adenosine receptor antagonist with slight selectivity for A1 receptors. Ecto-phosphodiesterase inhibitor.

  • CAS Number

    89073-57-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-(2,3,6,7-Tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)benzenesulfonic acid
  • Molecular weight

    392.40
  • Molecular formula

    C17H20N4O5S
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    DMSO, water (0.43 mg/ml)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Newell EA  et al. 2',3'-cAMP, 3'-AMP, 2'-AMP and adenosine inhibit TNF-a and CXCL10 production from activated primary murine microglia via A2A receptors. Brain Res 1594:27-35 (2015). Read more (PubMed: 25451117) »
  • Jackson EK & Gillespie DG Extracellular 2',3'-cAMP-adenosine pathway in proximal tubular, thick ascending limb, and collecting duct epithelial cells. Am J Physiol Renal Physiol 304:F49-55 (2013). Read more (PubMed: 23077101) »
  • Jackson EK  et al. Role of A1 receptors in renal sympathetic neurotransmission in the mouse kidney. Am J Physiol Renal Physiol 303:F1000-5 (2012). Read more (PubMed: 22874760) »
  • Jackson EK  et al. Extracellular 2,3-cyclic adenosine monophosphate is a potent inhibitor of preglomerular vascular smooth muscle cell and mesangial cell growth [corrected]. Hypertension 56:151-8 (2010). Read more (PubMed: 20516392) »

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