Overview

  • Product name

    14,15-EET, Cytochrome p450 product of arachidonic acid
  • Description

    Cytochrome p450 product of arachidonic acid
  • Biological description

    Cytochrome p450 metabolite of arachidonic acid (ab120916). Vasodilatory in vivo. Activates STAT-3 in human dermal microvascular endothelial cells. Induces angiogenesis.
  • Purity

    > 98%
  • CAS Number

    81276-03-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Falck JR  et al. 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition. J Med Chem 52:5069-75 (2009). Read more (PubMed: 19653681) »
  • Cheranov SY  et al. An essential role for SRC-activated STAT-3 in 14,15-EET-induced VEGF expression and angiogenesis. Blood 111:5581-91 (2008). Read more (PubMed: 18408167) »
  • Fitzpatrick FA  et al. Inhibition of cyclooxygenase activity and platelet aggregation by epoxyeicosatrienoic acids. Influence of stereochemistry. J Biol Chem 261:15334-8 (1986). Read more (PubMed: 3095326) »

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