14,15-Leukotriene C4 (eoxin C4), proinflammatory mediator (ab141697)

Overview

  • Product name

    14,15-Leukotriene C4 (eoxin C4), proinflammatory mediator
  • Description

    Potent proinflammatory mediator
  • Biological description

    Potent proinflammatory mediator. For in vitro use. Product of the lipoxygenase pathway and modulator of vascular permeability.
  • Purity

    > 98%
  • CAS Number

    75290-60-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (5Z,8Z,10E,12E,14R,15S)-14-[(2R)-2-[[(4S)-4-Amino-4-carboxybutanoyl]amino]-3-(carboxymethylamino)-3-oxopropyl]sulfanyl-15-hydroxyicosa-5,8,10,12-tetraenoic acid
  • Molecular weight

    625.77
  • Molecular formula

    C30H47N3O9S
  • PubChem identifier

    42607303
  • Storage instructions

    Store at -80°C.
  • Solubility overview

    Supplied in methanol/ammonium acetate buffer, 70/30, pH 5.6 (50 µg/ml)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCCCC(C(C=CC=CC=CCC=CCCCC(=O)O)SCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)N)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Ono E  et al. Concentration of 14,15-leukotriene C4 (eoxin C4) in bronchoalveolar lavage fluid. Clin Exp Allergy 39:1348-52 (2009). Read more (PubMed: 19438588) »
  • Feltenmark S  et al. Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells. Proc Natl Acad Sci U S A 105:680-5 (2008). Read more (PubMed: 18184802) »
  • Claesson HE  et al. Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma. FEBS J 275:4222-34 (2008). Read more (PubMed: 18647347) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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