Overview

  • Product name

    Anti-15-PGDH antibody (Phycoerythrin)
    See all 15-PGDH primary antibodies
  • Description

    Rabbit polyclonal to 15-PGDH (Phycoerythrin)
  • Host species

    Rabbit
  • Conjugation

    Phycoerythrin. Ex: 488nm, Em: 575nm
  • Tested applications

    Suitable for: Flow Cytmore details
  • Species reactivity

    Reacts with: Guinea pig, Cow, Human, Baboon
    Predicted to work with: Mouse, Rat, Pig, Cynomolgus monkey
  • Immunogen

    Synthetic peptide corresponding to Human 15-PGDH aa 92-105.
    Sequence:

    AGVNNEKNWEKTLQ

Properties

Applications

Our Abpromise guarantee covers the use of ab92754 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
  • Application notes
    Flow Cyt: Use at a concentration of 3 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.
    • Tissue specificity

      Detected in colon epithelium (at protein level).
    • Involvement in disease

      Defects in HPGD are the cause of primary hypertrophic osteoathropathy autosomal recessive (PHOAR) [MIM:259100]; also known as pachydermoperiostosis autosomal recessive. Primary hypertrophic osteoarthropathy is characterized by digital clubbing, osterarthropathy, variable features of pachydermia, delayed closure of the fontanels, and congenital heart disease.
      Defects in HPGD are the cause of cranioosteoarthropathy (COA) [MIM:259100]. Clinical features include infantile onset of swelling of the joints, digital clubbing, hyperhidrosis, delayed closure of the fontanels, periostosis, and variable patent ductus arteriosus. Pachydermia is not a prominent feature.
      Defects in HPGD are a cause of isolated congenital nail clubbing (ICNC) [MIM:119900]; also called clubbing of digits or hereditary acropachy. ICNC is a rare genodermatosis characterized by enlargement of the nail plate and terminal segments of the fingers and toes, resulting from proliferation of the connective tissues between the nail matrix and the distal phalanx. It is usually symmetrical and bilateral (in some cases unilateral). In nail clubbing usually the distal end of the nail matrix is relatively high compared to the proximal end, while the nail plate is complete but its dimensions and diameter more or less vary in comparison to normal. There may be different fingers and toes involved to varying degrees. Some fingers or toes are spared, but the thumbs are almost always involved.
    • Sequence similarities

      Belongs to the short-chain dehydrogenases/reductases (SDR) family.
    • Cellular localization

      Cytoplasm.
    • Information by UniProt
    • Database links

    • Alternative names

      • 15 hydroxyprostaglandin dehydrogenase [NAD+] antibody
      • 15 PGDH antibody
      • 15-hydroxyprostaglandin dehydrogenase [NAD+] antibody
      • 15-PGDH antibody
      • 15PGDH antibody
      • Hpgd antibody
      • Hydroxyprostaglandin dehydrogenase 15 (NAD) antibody
      • NAD+ dependent 15 hydroxyprostaglandin dehydrogenase antibody
      • OTTHUMP00000218960 antibody
      • OTTHUMP00000219016 antibody
      • OTTHUMP00000219018 antibody
      • PGDH antibody
      • PGDH_HUMAN antibody
      • PGDH1 antibody
      • PHOAR1 antibody
      • Prostaglandin dehydrogenase 1 antibody
      • SDR36C1 antibody
      • Short chain dehydrogenase/reductase family 36C member 1 antibody
      see all

    References

    ab92754 has not yet been referenced specifically in any publications.

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