Overview

  • Product name

    15(S)-HpETE, Prostacyclin synthase inhibitor
  • Description

    Prostacyclin synthase inhibitor
  • Biological description

    Prostacyclin synthase inhibitor. In vivo and in vitro use. Lipoxygenase pathway. Inhibits platelet aggregation.
  • Purity

    > 98%
  • CAS Number

    70981-96-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (5E,8Z,11Z,13Z,15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoic acid
  • Molecular weight

    336.50
  • Molecular formula

    C20H32O4
  • PubChem identifier

    6439775
  • Storage instructions

    Store at -80°C.
  • Solubility overview

    Supplied in ethanol (50 µg/ml)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCCCC(C=CC=CCC=CCC=CCCCC(=O)O)OO
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Soumya SJ  et al. Effect of 15-lipoxygenase metabolites on angiogenesis: 15(S)-HPETE is angiostatic and 15(S)-HETE is angiogenic. Inflamm Res 61:707-18 (2012). Read more (PubMed: 22450700) »
  • Sordillo LM  et al. Enhanced 15-HPETE production during oxidant stress induces apoptosis of endothelial cells. Prostaglandins Other Lipid Mediat 76:19-34 (2005). Read more (PubMed: 15967159) »
  • Matsuda H  et al. Pharmacodynamics of 15(S)-hydroperoxyeicosatetraenoic (15-HPETE) and 15(S)-hydroxyeicosatetraenoic acid (15-HETE) in isolated arteries from guinea pig, rabbit, rat and human. J Pharmacol Exp Ther 273:1182-9 (1995). Read more (PubMed: 7791089) »

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