Overview

  • Product name

    16-Oxokahweol, Synthetic kahweol derivative
  • Description

    Synthetic kahweol derivative. Glutathione S-transferase inducer.
  • Biological description

    Synthetic kahweol (ab143500) derivative. Glutathione S-transferase inducer. Putative anticarcinogenic agent. Orally active.
  • Purity

    > 95%
  • CAS Number

    108664-99-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (3bS,5aS,8R,10aR,10bS)-3b,4,5,6,7,8,9,10,10a,10b-Decahydro-10b-methyl-5a,8-methano-7-oxo-5aH-cyclohepta[5,6]naphtho[2,1-b]furan
  • Molecular weight

    282.38
  • Molecular formula

    C19H22O2
  • PubChem identifier

    71308325
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC12C=CC3=C(C1CCC45C2CCC(C4)C(=O)C5)C=CO3
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Cavin C  et al. Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity. Food Chem Toxicol 40:1155-63 (2002). Read more (PubMed: 12067578) »
  • Post SM  et al. Cafestol, the cholesterol-raising factor in boiled coffee, suppresses bile acid synthesis by downregulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase in rat hepatocytes. Arterioscler Thromb Vasc Biol 17:3064-70 (1997). Read more (PubMed: 9409294) »
  • Lam LK  et al. Effects of derivatives of kahweol and cafestol on the activity of glutathione S-transferase in mice. J Med Chem 30:1399-403 (1987). Read more (PubMed: 3612687) »

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