17beta-Estradiol, Selective agonist of ER receptor (ab120657)

Submit a review Q&A (1)References (9)

Overview

  • Product name

    17beta-Estradiol, Selective agonist of ER receptor

  • Description

    Selective agonist of ER receptor

  • Biological description

    Selective agonist of ER receptor. Binds to ERα and ERβ receptors (Ki values are 0.13 and 0.12 nM, respectively). Agonist at the GPR30 receptor, activates PI3K.

  • Purity

    > 99%

  • CAS Number

    50-28-2

  • Chemical structure

    Chemical Structure

Properties

Images

  • Functional Studies - 17beta-Estradiol, Selective agonist of ER receptor (ab120657)
    Functional Studies - 17beta-Estradiol, Selective agonist of ER receptor (ab120657)Xiao et al PLoS One. 2014; 9(5): e95878. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/

    ERα ligands regulate the expression of CLOCK at the transcription level.

    Analysis of CLOCK mRNA levels in MCF-7 cells by real-time PCR. MCF-7 cells were cultured in phenol red free medium and charcoal striped FCS medium for 2 days before being treated with E2 and the expression of CLOCK was then analyzed by real-time PCR.

    E2 = 17beta-Estradiol.

    (From Figure 3A of Xiao et al).

References

This product has been referenced in:

  • Hernández-Fonseca K  et al. Neuroprotective Role of Estradiol against Neuronal Death Induced by Glucose Deprivation in Cultured Rat Hippocampal Neurons. Neuroendocrinology : (2011). Read more (PubMed: 22213775) »
  • Maggiolini M & Picard D The unfolding stories of GPR30, a new membrane-bound estrogen receptor. J Endocrinol 204:105-14 (2010). Read more (PubMed: 19767412) »
  • Thomas P  et al. Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology 146:624-32 (2005). Read more (PubMed: 15539556) »
  • Kuiper GG  et al. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 138:863-70 (1997). Read more (PubMed: 9048584) »
See all 9 Publications for this product

Publishing research using ab120657? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

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Question



Also, has it been tested in mice? Finally, is it water soluble? We plan for 3, 0.5mg subcutaneous injections in rodents every other day. Sigma-Aldrich used to provide a safe, water soluble version of this product, but has since migrated to an in-house production that now kills mice. I am hoping your product doesn't do that. Thank you.

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Answer

Thank you for contacting us.
We have tested the solubility of this product in our lab and found that it is soluble in DMSO and in ethanol to the limits stated on the datasheet; this product is not soluble in water. Unfortunately, we do not offer a water soluble version of this product, however do offer the synthetic ester and prodrug 17b-estradiol valerate (ab143321).
I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.
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