Key features and details
- Selective agonist of ER receptor
- CAS Number: 50-28-2
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 75 mM
- Form / State: Solid
- Source: Synthetic
Product name17beta-Estradiol, Selective agonist of ER receptor
DescriptionSelective agonist of ER receptor
Selective agonist of ER receptor. Binds to ERα and ERβ receptors (Ki values are 0.13 and 0.12 nM, respectively). Agonist at the GPR30 receptor, activates PI3K.
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 75 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
2D chemical structure image of ab120657, 17beta-Estradiol, Selective agonist of ER receptor
ERα ligands regulate the expression of CLOCK at the transcription level.
Analysis of CLOCK mRNA levels in MCF-7 cells by real-time PCR. MCF-7 cells were cultured in phenol red free medium and charcoal striped FCS medium for 2 days before being treated with E2 and the expression of CLOCK was then analyzed by real-time PCR.
E2 = 17beta-Estradiol.
(From Figure 3A of Xiao et al).
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120657 has been referenced in 13 publications.
- Alahmadi AA et al. Both Matricaria chamomilla and Metformin Extract Improved the Function and Histological Structure of Thyroid Gland in Polycystic Ovary Syndrome Rats through Antioxidant Mechanism. Biomolecules 10:N/A (2020). PubMed: 31948119
- Zha B et al. GPR30 Promotes the Phenotypic Switching of Vascular Smooth Muscle Cells via Activating the AKT and ERK Pathways. Onco Targets Ther 13:3801-3808 (2020). PubMed: 32440148
- Yotsumoto F et al. Adipose tissue-derived regenerative cells improve implantation of fertilized eggs in thin endometrium. Regen Med 15:1891-1904 (2020). PubMed: 32698666
- Zhang YY et al. GPR30-mediated estrogenic regulation of actin polymerization and spatial memory involves SRC-1 and PI3K-mTORC2 in the hippocampus of female mice. CNS Neurosci Ther N/A:N/A (2019). PubMed: 30714337
- Sun T et al. Hippocampus-specific Rictor knockdown inhibited 17ß-estradiol induced neuronal plasticity and spatial memory improvement in ovariectomized mice. Behav Brain Res 364:50-61 (2019). PubMed: 30753873