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17beta-Estradiol, Selective agonist of ER receptor (ab120657)

  • Datasheet
  • SDS
  • COA
Submit a review Q&A (1)References (13)

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Chemical Structure - 17beta-Estradiol, Selective agonist of ER receptor (ab120657)
  • Functional Studies - 17beta-Estradiol, Selective agonist of ER receptor (ab120657)

Key features and details

  • Selective agonist of ER receptor
  • CAS Number: 50-28-2
  • Purity: > 99%
  • Soluble in DMSO to 100 mM and in ethanol to 75 mM
  • Form / State: Solid
  • Source: Synthetic

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Overview

  • Product name

    17beta-Estradiol, Selective agonist of ER receptor
  • Description

    Selective agonist of ER receptor
  • Biological description

    Selective agonist of ER receptor. Binds to ERα and ERβ receptors (Ki values are 0.13 and 0.12 nM, respectively). Agonist at the GPR30 receptor, activates PI3K.

  • Purity

    > 99%
  • CAS Number

    50-28-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    17β-Estra-1,3,5(10)-triene-3,17-diol
  • Molecular weight

    272.38
  • Molecular formula

    C18H24O2
  • PubChem identifier

    5757
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 75 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

  • Research areas

    • Epigenetics and Nuclear Signaling
    • Transcription
    • Domain Families
    • Zinc Finger
    • Signal Transduction
    • Signaling Pathway
    • Nuclear Signaling
    • Nuclear Hormone Receptors
    • Estrogen
    • Neuroscience
    • Endocrine system
    • Gonadotrophic axis
    • Epigenetics and Nuclear Signaling
    • Nuclear Signaling Pathways
    • Nuclear Receptors
    • Estrogen
    • Cancer
    • Signal transduction
    • Nuclear signaling
    • Nuclear hormone receptors
    • Estrogen
    • Cancer
    • Tumor biomarkers
    • Receptors
    • Biochemicals
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Associated products

    Images

    • Chemical Structure - 17beta-Estradiol, Selective agonist of ER receptor (ab120657)
      Chemical Structure - 17beta-Estradiol, Selective agonist of ER receptor (ab120657)
      2D chemical structure image of ab120657, 17beta-Estradiol, Selective agonist of ER receptor
    • Functional Studies - 17beta-Estradiol, Selective agonist of ER receptor (ab120657)
      Functional Studies - 17beta-Estradiol, Selective agonist of ER receptor (ab120657)Xiao et al PLoS One. 2014; 9(5): e95878. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/

      ERα ligands regulate the expression of CLOCK at the transcription level.

      Analysis of CLOCK mRNA levels in MCF-7 cells by real-time PCR. MCF-7 cells were cultured in phenol red free medium and charcoal striped FCS medium for 2 days before being treated with E2 and the expression of CLOCK was then analyzed by real-time PCR.

      E2 = 17beta-Estradiol.

      (From Figure 3A of Xiao et al).

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download
    • COA

    References (13)

    Publishing research using ab120657? Please let us know so that we can cite the reference in this datasheet.

    ab120657 has been referenced in 13 publications.

    • Alahmadi AA  et al. Both Matricaria chamomilla and Metformin Extract Improved the Function and Histological Structure of Thyroid Gland in Polycystic Ovary Syndrome Rats through Antioxidant Mechanism. Biomolecules 10:N/A (2020). PubMed: 31948119
    • Zha B  et al. GPR30 Promotes the Phenotypic Switching of Vascular Smooth Muscle Cells via Activating the AKT and ERK Pathways. Onco Targets Ther 13:3801-3808 (2020). PubMed: 32440148
    • Yotsumoto F  et al. Adipose tissue-derived regenerative cells improve implantation of fertilized eggs in thin endometrium. Regen Med 15:1891-1904 (2020). PubMed: 32698666
    • Zhang YY  et al. GPR30-mediated estrogenic regulation of actin polymerization and spatial memory involves SRC-1 and PI3K-mTORC2 in the hippocampus of female mice. CNS Neurosci Ther N/A:N/A (2019). PubMed: 30714337
    • Sun T  et al. Hippocampus-specific Rictor knockdown inhibited 17ß-estradiol induced neuronal plasticity and spatial memory improvement in ovariectomized mice. Behav Brain Res 364:50-61 (2019). PubMed: 30753873
    View all Publications for this product

    Customer reviews and Q&As

    Show All Reviews Q&A
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    Question



    Also, has it been tested in mice? Finally, is it water soluble? We plan for 3, 0.5mg subcutaneous injections in rodents every other day. Sigma-Aldrich used to provide a safe, water soluble version of this product, but has since migrated to an in-house production that now kills mice. I am hoping your product doesn't do that. Thank you.

    Read More

    Abcam community

    Verified customer

    Asked on Aug 26 2014

    Answer

    Thank you for contacting us.
    We have tested the solubility of this product in our lab and found that it is soluble in DMSO and in ethanol to the limits stated on the datasheet; this product is not soluble in water. Unfortunately, we do not offer a water soluble version of this product, however do offer the synthetic ester and prodrug 17b-estradiol valerate (ab143321).
    I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.
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    Can’t find the antibody you need? Try our Custom RabMAb® services.
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    Heather Allen

    Abcam Scientific Support

    Answered on Aug 26 2014

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
    For licensing inquiries, please contact partnerships@abcam.com

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