18beta-Glycyrrhetinic acid (Enoxolone), Gap junction inhibitor (ab142579)

Overview

  • Product name

    18beta-Glycyrrhetinic acid (Enoxolone), Gap junction inhibitor
  • Description

    Gap junction inhibitor
  • Alternative names

    • Enoxolone
  • Biological description

    Gap junction inhibitor. Antiviral activity against rotavirus replication in vitro. Shows immunomodulatory, chemopreventive and anti-inflammatory effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    471-53-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid
  • Molecular weight

    470.68
  • Molecular formula

    C30H46O4
  • PubChem identifier

    10114
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1(C2CCC3(C(C2(CCC1O)C)C(=O)C=C4C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Hardy ME  et al. 18ß-glycyrrhetinic acid inhibits rotavirus replication in culture. Virol J 9:96 (2012). Read more (PubMed: 22616823) »
  • Hendricks JM  et al. 18ß-glycyrrhetinic acid delivered orally induces isolated lymphoid follicle maturation at the intestinal mucosa and attenuates rotavirus shedding. PLoS One 7:e49491 (2012). Read more (PubMed: 23152913) »
  • Asl MN & Hosseinzadeh H Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds. Phytother Res 22:709-24 (2008). Read more (PubMed: 18446848) »
See 1 Publication for this product

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