1alpha-Hydroxyvitamin D3 (Alfacalcidol), Bone resorption inhibitor (ab142686)

Overview

  • Product name

    1alpha-Hydroxyvitamin D3 (Alfacalcidol), Bone resorption inhibitor
  • Description

    Bone resorption inhibitor. Metabolite of cholecalciferol.
  • Alternative names

    • Alfacalcidol
  • Biological description

    Metabolite of cholecalciferol (ab143594). Shows osteoprotective effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    41294-56-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-Methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
  • Molecular weight

    400.64
  • Molecular formula

    C27H44O2
  • PubChem identifier

    5282181
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM (with warming) and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)CCCC(C)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Khajuria DK  et al. Osteoprotective effect of propranolol in ovariectomized rats: a comparison with zoledronic acid and alfacalcidol. J Orthop Sci 18:832-42 (2013). Read more (PubMed: 23835529) »
  • Suda T  et al. Bone effects of vitamin D - Discrepancies between in vivo and in vitro studies. Arch Biochem Biophys 523:22-9 (2012). Read more (PubMed: 22107950) »
  • Miyakoshi N  et al. Effects of a vitamin D analog, alfacalcidol, on bone and skeletal muscle in glucocorticoid-treated rats. Biomed Res 31:329-36 (2010). Read more (PubMed: 21187643) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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