1Kbeta-Pompilidotoxin, slows Na+-channel inactivation (ab141836)

Overview

  • Product name

    1Kbeta-Pompilidotoxin, slows Na+-channel inactivation
  • Description

    Slows the Na+-channel inactivation
  • Alternative names

    • 1Kβ-PMTX
  • Biological description

    Slows the Na+-channel inactivation. Mutated form of the β-Pompilidotoxin (ab141835). Slows the inactivation of TTX-sensitive Na+ channels. Selective for neuronal Na+ currents. Potentiates synaptic transmission in vivo with greater potency than α-Pompilidotoxin (Asc 1834) .
  • Purity

    > 98%
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    1531.00
  • Molecular formula

    C71H124N20O17
  • Sequence

    KIKIGLFDQLSRL (Modifications: C-terminal amide)
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Magloire V  et al. ß-pompilidotoxin modulates spontaneous activity and persistent sodium currents in spinal networks. Neuroscience 172:129-38 (2011). Read more (PubMed: 20955768) »
  • Kinoshita E  et al. Novel wasp toxin discriminates between neuronal and cardiac sodium channels. Mol Pharmacol 59:1457-63 (2001). Read more (PubMed: 11353806) »
  • Konno K  et al. Isolation and structure of pompilidotoxins, novel peptide neurotoxins in solitary wasp venoms. Biochem Biophys Res Commun 250:612-6 (1998). Read more (PubMed: 9784394) »

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