2-(1,8-Naphthyridin-2-ly)phenol,  STAT1 transcriptional activator (ab142704)

Overview

  • Product name

    2-(1,8-Naphthyridin-2-ly)phenol,  STAT1 transcriptional activator
  • Description

    Selective STAT1 transcriptional activator. Cell-permeable.
  • Biological description

    Selective STAT1 transcriptional activator. No effect on unrelated transcription factors NF-κB or STAT3. Enhances ability of IFN-γ to inhibit cancer cells in vitro. Antitumor agent. Active in vitro. Cell-permeable.
  • Purity

    > 98%
  • CAS Number

    65182-56-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6-(1H-1,8-Naphthyridin-2-ylidene)cyclohexa-2,4-dien-1-one
  • Molecular weight

    222.24
  • Molecular formula

    C14H10N2O
  • PubChem identifier

    6789423
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC(=C2C=CC3=C(N2)N=CC=C3)C(=O)C=C1
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Lynch RA  et al. A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of IFN-gamma in human cancer cells. Cancer Res 67:1254-61 (2007). Read more (PubMed: 17283162) »

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