2-APB, Ca2+ release modulator (ab120124)
Key features and details
- Ca2+ release modulator
- CAS Number: 524-95-8
- Soluble in DMSO to 100 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
2-APB, Ca2+ release modulator -
Description
Ca2+ release modulator -
Biological description
Cell-permeable, allosteric inhibitor of D-myo-inositol 1,4,5-trisphosphate (IP3) -induced Ca2+ release . Inhibits IP3-induced Ca2+ release without affecting IP3 receptor binding. Blocks store operated Ca2+ entry.
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CAS Number
524-95-8 -
Chemical structure
Properties
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Chemical name
2-Aminoethyl diphenylborinate -
Molecular weight
225.10 -
Molecular formula
C14H16BNO -
PubChem identifier
1598 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
NCCOB(c1ccccc1)c2ccccc2 -
Source
Synthetic
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Research areas
- Signal Transduction
- Signaling Pathway
- Nuclear Signaling
- Nuclear Hormone Receptors
- Vitamin D Receptor
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipoprotein metabolism
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipases
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Fatty acids
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Signal transduction
- Inositol & cAMP signaling
- Inositol lipids
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Signal transduction
- Inositol & cAMP signaling
- Inositol lipids
- Biochemicals
- Research Area
- Hypertension
- Signaling
- Signal transduction
- Inositol & cAMP signaling
- Inositol lipids
- Biochemicals
- Research Area
- Obesity
- Signaling
- Signal transduction
- Inositol & cAMP signaling
- Inositol lipids
Images
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2D chemical structure image of ab120124, 2-APB, Ca2+ release modulator
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Induction of mGluR1-mediated inward current requires activation of TRPC1 but not TRPC3 in MLIs.
Time courses of the effects of SKF96365 (black circles, 30 µM, n = 4) and 2-APB (gray circles, 100 µM, n = 5) on the DHPG-induced inward current. A black bar indicates the time of drug application.
(From Figure 2 B of Kubota et al).
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (19)
ab120124 has been referenced in 19 publications.
- Yang J et al. Mitochondria-associated membrane protein PACS2 maintains right cardiac function in hypobaric hypoxia. iScience 26:106328 (2023). PubMed: 36968068
- Lin C et al. Functional imaging-guided cell selection for evolving genetically encoded fluorescent indicators. Cell Rep Methods 3:100544 (2023). PubMed: 37671014
- Li C et al. PINK1-Dependent Mitophagy Reduced Endothelial Hyperpermeability and Cell Migration Capacity Under Simulated Microgravity. Front Cell Dev Biol 10:896014 (2022). PubMed: 35874841
- Andriulė I et al. Detection of TRPM6 and TRPM7 Proteins in Normal and Diseased Cardiac Atrial Tissue and Isolated Cardiomyocytes. Int J Mol Sci 23:N/A (2022). PubMed: 36499188
- Dantas M et al. Nuclear tension controls mitotic entry by regulating cyclin B1 nuclear translocation. J Cell Biol 221:N/A (2022). PubMed: 36222828