2-Acetyl-4-(1(R),2(S),3(R),4-tetrahydroxybutyl)imidazole, sphingosine-1-phosphate lyase inhibitor (ab144103)

Overview

  • Product name

    2-Acetyl-4-(1(R),2(S),3(R),4-tetrahydroxybutyl)imidazole, sphingosine-1-phosphate lyase inhibitor
  • Description

    Inhibitor of sphingosine-1-phosphate lyase
  • Alternative names

    • 2-Acetyl-4-tetrahydroxybutylimidazole
    • 2-ATHBI
    • THI
  • Biological description

    Inhibitor of sphingosine-1-phosphate lyase. Induces lymphopenia, affects lymphocyte migration and degradation. Immunosuppressive potential. Use in sphingolipid studies. Active in vivo.
  • Purity

    > 99%
  • CAS Number

    94944-70-4
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Yu XQ  et al. Pharmacokinetic/pharmacodynamic modelling of 2-acetyl-4(5)-tetrahydroxybutyl imidazole-induced peripheral lymphocyte sequestration through increasing lymphoid sphingosine 1-phosphate. Xenobiotica 40:350-6 (2010). Read more (PubMed: 20175664) »
  • Gobin SJ  et al. The role of lymphocyte production and migration in the lymphopenia caused by 2-acetyl-4-tetrahydroxybutyl imidazole. Int J Immunopharmacol 14:687-97 (1992). Read more (PubMed: 1521936) »
  • Gobin SJ & Phillips JA Immunosuppressive effects of 2-acetyl-4-tetrahydroxybutyl imidazole (THI) in the rat. Clin Exp Immunol 85:335-40 (1991). Read more (PubMed: 1864015) »

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