Overview

  • Product name
    2-Aminobiphenyl, Mutagenic agent
  • Description
    Mutagenic agent
  • Biological description
    Mutagenic agent. Upregulates COX-2 expression in cancer cells. Induces oxidative DNA damage via ROS generation. Shows carcinogenic effects in vivo.
  • CAS Number
    90-41-5
  • Chemical structure
    Chemical Structure

Properties

References

This product has been referenced in:
  • Chen CC  et al. Cyclooxygenase-2 expression is up-regulated by 2-aminobiphenyl in a ROS and MAPK-dependent signaling pathway in a bladder cancer cell line. Chem Res Toxicol 25:695-705 (2012). Read more (PubMed: 22288910) »
  • Wang SC  et al. 2- and 4-Aminobiphenyls induce oxidative DNA damage in human hepatoma (Hep G2) cells via different mechanisms. Mutat Res 593:9-21 (2006). Read more (PubMed: 16112689) »
  • Kajbaf M & Gorrod JW Metabolism of [14C]2-aminobiphenyl in vivo by different species. Eur J Drug Metab Pharmacokinet 12:285-90 (0). Read more (PubMed: 3449387) »

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