Overview

  • Product name

    2-Arachidonoyl glycerol-d8, endogenous CB1 agonist
  • Description

    Potent, endogenous CB1 agonist
  • Biological description

    Endogenous potent CB1 agonist (EC50 values are 519 and 618 nM at CB1 and CB2, respectively). Agonist activity also seen at GPR55 orphan receptor (EC50 = 3 nM). Able to induce a rapid and transient increases in intracellular Ca2+ concentrations in vitro. Abundantly expressed in the brain.
  • Purity

    > 99%
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Sugiura T  et al. Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells. J Biol Chem 275:605-12 (2000). Read more (PubMed: 10617657) »
  • Sugiura T  et al. Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds. J Biol Chem 274:2794-801 (1999). Read more (PubMed: 9915812) »
  • Kondo S  et al. 2-Arachidonoylglycerol, an endogenous cannabinoid receptor agonist: identification as one of the major species of monoacylglycerols in various rat tissues, and evidence for its generation through CA2+-dependent and -independent mechanisms. FEBS Lett 429:152-6 (1998). Read more (PubMed: 9650580) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab120919.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up