Overview

  • Product name
    2-Deoxy-D-glucose, glucose analog
  • Description
    Non-metabolizable glucose analog and glycolytic inhibitor. Antitumor agent.
  • Biological description
    Non-metabolizable glucose analog and glycolytic inhibitor. Competitive phosphoglucose isomerase inhibitor. Induces ROS-dependent autophagy (EC50 = 100 μM) and depletes cellular ATP. Antitumor and antiproliferative activity in vivo and in vitro. Orally active.
  • Purity
    > 98%
  • CAS Number
    154-17-6
  • Chemical structure
    Chemical Structure

Properties

References

This product has been referenced in:
  • Xi H  et al. 2-Deoxy-D-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion. Cancer Chemother Pharmacol 67:899-910 (2011). Read more (PubMed: 20593179) »
  • Wang Q  et al. 2-Deoxy-D-glucose treatment of endothelial cells induces autophagy by reactive oxygen species-mediated activation of the AMP-activated protein kinase. PLoS One 6:e17234 (2011). Read more (PubMed: 21386904) »
  • Kang HT & Hwang ES 2-Deoxyglucose: an anticancer and antiviral therapeutic, but not any more a low glucose mimetic. Life Sci 78:1392-9 (2006). Read more (PubMed: 16111712) »
See 1 Publication for this product

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