Product name2'-Deoxy-D-ribose, endothelial-cell chemoattractant
DescriptionEndothelial-cell chemoattractant and angiogenesis-inducing factor.
Reducing sugar used to study processes of oxidative stress and glycation in vivo and in vitro. Induces apoptosis by inhibiting the synthesis and increasing the efflux of glutathione. Endothelial-cell chemoattractant and angiogenesis-inducing factor, used to study processes of tumor angiogenesis and progression, mediated at the level of thymidine phosphorylase activity.
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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This product has been referenced in:
- Koh G et al. Intracellular glutathione production, but not protein glycation, underlies the protective effects of captopril against 2-deoxy-D-ribose-induced ß-cell damage. Mol Med Rep 12:5314-20 (2015). Read more (PubMed: 26151175) »
- Koh G et al. 2-Deoxy-D-ribose induces cellular damage by increasing oxidative stress and protein glycation in a pancreatic beta-cell line. Metabolism 59:325-32 (2010). Read more (PubMed: 19793592) »
- Nakajima Y et al. 2-Deoxy-D-ribose, a downstream mediator of thymidine phosphorylase, regulates tumor angiogenesis and progression. Anticancer Agents Med Chem 9:239-45 (2009). Read more (PubMed: 19199868) »
- Kletsas D et al. The highly reducing sugar 2-deoxy-D-ribose induces apoptosis in human fibroblasts by reduced glutathione depletion and cytoskeletal disruption. Biochem Biophys Res Commun 243:416-25 (1998). Read more (PubMed: 9480824) »
- Brown NS & Bicknell R Thymidine phosphorylase, 2-deoxy-D-ribose and angiogenesis. Biochem J 334 ( Pt 1):1-8 (1998). Read more (PubMed: 9693094) »