2'-Deoxyuridine-5'-monophosphate disodium salt, reference substrate for dUMP analogs (ab146224)

Overview

  • Product name

    2'-Deoxyuridine-5'-monophosphate disodium salt, reference substrate for dUMP analogs
  • Description

    Reference substrate for dUMP analogs.
  • Alternative names

    • 2'-Deoxy-5'-uridylic acid disodium salt
    • 2'-dUMP·2Na
    • dUMP disodium salt
  • Biological description

    Used by the enzyme thymidylate synthetase (TS) (EC 2.1.1.45) for the de novo production of dTMP. Reference substrate in studies of dUMP analogs in potential chemotherapy applications.

  • Purity

    > 98%
  • CAS Number

    42155-08-8
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    352.10
  • Molecular formula

    C9H11N2Na2O8P
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Koehn EM  et al. An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene. Nature 458:919-23 (2009). Read more (PubMed: 19370033) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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