2-Guanidinoethylmercaptosuccinic acid (GEMSA), carboxypeptidase B2 (TAFIa) inhibitor (ab145054)

Overview

  • Product name

    2-Guanidinoethylmercaptosuccinic acid (GEMSA), carboxypeptidase B2 (TAFIa) inhibitor
  • Description

    Competitive carboxypeptidase B2 (TAFIa) inhibitor
  • Biological description

    Competitive carboxypeptidase B2 (TAFIa) inhibitor. Shows complex fibrinolytic effects prolonging or shortening fibrinolysis.
  • Purity

    > 97%
  • CAS Number

    77482-44-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[[2-[(Aminoiminomethyl)amino]ethyl]thio]butanedioic acid
  • Molecular weight

    235.26
  • Molecular formula

    C7H13N3O4S
  • PubChem identifier

    3464
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    NC(=N)NCCSC(CC(=O)O)C(=O)O
  • Source

    Synthetic

References

This product has been referenced in:

  • Walker JB  et al. Stabilization versus inhibition of TAFIa by competitive inhibitors in vitro. J Biol Chem 278:8913-21 (2003). Read more (PubMed: 12643276) »
  • Boffa MB  et al. Plasma and recombinant thrombin-activable fibrinolysis inhibitor (TAFI) and activated TAFI compared with respect to glycosylation, thrombin/thrombomodulin-dependent activation, thermal stability, and enzymatic properties. J Biol Chem 273:2127-35 (1998). Read more (PubMed: 9442053) »
  • Bajzar L  et al. The profibrinolytic effect of activated protein C in clots formed from plasma is TAFI-dependent. Blood 88:2093-100 (1996). Read more (PubMed: 8822928) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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