2-Hydroxyflutamide, androgen receptor antagonist (ab143636)

Overview

  • Product name

    2-Hydroxyflutamide, androgen receptor antagonist
  • Description

    Potent androgen receptor antagonist
  • Biological description

    Potent androgen receptor antagonist (IC50 = 15 nM). Flutamide (ab141234) metabolite. Antiproliferative agent but attenuates induction of granulosa cell apoptosis in the presence of a high T level. Active in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    52806-53-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
  • Molecular weight

    292.21
  • Molecular formula

    C11H11F3N2O4
  • PubChem identifier

    91649
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)(C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Duda M  et al. The impact of antiandrogen 2-hydroxyflutamide on the expression of steroidogenic enzymes in cultured porcine ovarian follicles. Mol Biol Rep 41:4213-22 (2014). Read more (PubMed: 24584661) »
  • Duda M  et al. Does 2-hydroxyflutamide inhibit apoptosis in porcine granulosa cells? - An in vitro study. J Reprod Dev 58:438-44 (2012). Read more (PubMed: 22522230) »
  • Wang HX  et al. Cytotoxicity of flutamide and 2-hydroxyflutamide and their effects on CYP1A2 mRNA in primary rat hepatocytes. Acta Pharmacol Sin 23:562-6 (2002). Read more (PubMed: 12060533) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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