- References (1)
Product name2-Hydroxypropyl-beta-cyclodextrin, modified cyclodextrin
DescriptionWidely used modified cyclodextrin.
- beta-Cyclodextrin 2-Hydroxypropyl Ethers
Cyclic oligosaccharide containing seven D-(+)-glucopyranose units that is widely used to improve the aqueous solubility of various compounds, especially those containing a phenyl group. The circular arrangement of its glucose units produces a torus-shaped ring configuration in which the CH2 groups and ether linkages of the molecule face the hollow interior, resulting in a nonpolar, hydrophobic cavity and a polar, hydrophilic exterior. When combined in solution with other compounds, the nonpolar aromatic portions of that compound interact with the nonpolar interior of the HP-β-CD molecule, thus isolating the aromatic portion of the molecule from the water and thereby increasing its aqueous solubility.
Storage instructionsStore at +4°C. The product can be stored for up to 12 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Rao VM et al. Co-solubilization of poorly soluble drugs by micellization and complexation. Int J Pharm 319:98-106 (2006). Read more (PubMed: 16765542) »
- Frijlink HW et al. The effects of cyclodextrins on the disposition of intravenously injected drugs in the rat. Pharm Res 8:380-4 (1991). Read more (PubMed: 2052529) »