2-Hydroxytetradecanoic acid, 2-Hydroxy C14:0 analog of myristic acid (ab144006)

Overview

  • Product name

    2-Hydroxytetradecanoic acid, 2-Hydroxy C14:0 analog of myristic acid
  • Description

    2-Hydroxy C14:0 analog of myristic acid
  • Alternative names

    • 2-Hydroxymyristic acid
    • alpha-Hydroxymyristic acid
  • Biological description

    2-Hydroxy C14:0 analog of myristic acid. Forms 2-hydroxymyristoyl-CoA intracellularly. Blocks p56lck signaling and T-cell activation. Inhibits protein myristoylation at 0.5 mM. Potential antiviral agent. Active in vitro.
  • Purity

    > 98%
  • CAS Number

    2507-55-3
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Harper DR  et al. Inhibition of varicella-zoster virus replication by an inhibitor of protein myristoylation. J Gen Virol 74 ( Pt 6):1181-4 (1993). Read more (PubMed: 8389801) »
  • Paige LA  et al. Reversible palmitoylation of the protein-tyrosine kinase p56lck. J Biol Chem 268:8669-74 (1993). Read more (PubMed: 8473310) »
  • Paige LA  et al. Metabolic activation of 2-substituted derivatives of myristic acid to form potent inhibitors of myristoyl CoA:protein N-myristoyltransferase. Biochemistry 29:10566-73 (1990). Read more (PubMed: 2271666) »

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