Key features and details
- Bcl-xL and Bcl-2 inhibitor. Apoptotic.
- CAS Number:
- Purity: > 98%
- Soluble in DMSO to 10 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
Product name2-Methoxyantimycin A3, Bcl-xL and Bcl-2 inhibitor
DescriptionBcl-xL and Bcl-2 inhibitor. Apoptotic.
Biological descriptionBcl-xL and Bcl-2 inhibitor. Antiapoptotic. Depolarizes mitochrondrial membrane potential. Reduces tumor size in vivo without toxicity.
Chemical name2-Methoxyantimycin A3
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 10 mM and in ethanol to 10 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141523 has been referenced in 2 publications.
- Yang Z et al. CircPTK2 (hsa_circ_0003221) Contributes to Laryngeal Squamous Cell Carcinoma by the miR-1278/YAP1 Axis. J Oncol 2021:2408384 (2021). PubMed: 34691176
- Zhang D et al. Hepatoprotective effect of Xiayuxue decoction ethyl acetate fraction against carbon tetrachloride-induced liver fibrosis in mice via inducing apoptosis and suppressing activation of hepatic stellate cells. Pharm Biol 58:1229-1243 (2020). PubMed: 33332219