Product name2-(N-Hexadecanoylamino)-4-nitrophenylphosphocholine hydroxide, Niemann-Pick disease indicator
DescriptionIndicator used in the detection and diagnosis of Niemann-Pick disease.
- 2-[[Hydroxy[4-nitro-2-[(1-oxohexadecyl)amino]phenoxy]phosphinyl]oxy]-N,N,N-trimethyl-ethanaminium Hydroxide
- 2-Hexadecanoylamino-4-nitrophenylphosphorylcholine hyroxide
Indicator used in the detection and diagnosis of Niemann-Pick disease. Synthetic chromogenic analog of sphingomyelin which selectively measures the activity of acid sphingomyelinase (ASM). The production of ASM is inhibited in Niemann-Pick disease, allowing sphingomyelin to accumulate in the organs of affected persons.
Chemical name2-[[Hydroxy[4-nitro-2-[(1-oxohexadecyl)amino]phenoxy]phosphinyl]oxy]-N,N,N-trimethylethanaminium hydroxide
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewDMSO, water
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Levade T et al. Comparative hydrolysis of sphingomyelin and 2-N-(hexadecanoyl)-amino-4-nitrophenyl-phosphorylcholine by normal human brain homogenate at acid and neutral pH. J Neurochem 40:1762-4 (1983). Read more (PubMed: 6304255) »
- Gal AE & Fash FJ Synthesis of 2-n-(hexadecanoyl)-amino-4-nitrophenyl phosphorylcholine-hydroxide, a chromogenic substrate for assaying sphingomyelinase activity. Chem Phys Lipids 16:71-9 (1976). Read more (PubMed: 177220) »