Product name2-Phenyl-2-(1-piperidinyl)propane, CYP2B6 inactivator
DescriptionSelective CYP2B6 inactivator
Selective inactivator of CYP2B6 (Ki = 5.6 µM; IC50 = 5.1 µM).
Storage instructionsStore at +4°C. The product can be stored for up to 12 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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This product has been referenced in:
- Walsky RL & Obach RS A comparison of 2-phenyl-2-(1-piperidinyl)propane (ppp), 1,1',1''-phosphinothioylidynetrisaziridine (thioTEPA), clopidogrel, and ticlopidine as selective inactivators of human cytochrome P450 2B6. Drug Metab Dispos 35:2053-9 (2007). Read more (PubMed: 17682072) »
- Chun J et al. Mechanism-based inactivation of cytochromes P450 2B1 and P450 2B6 by 2-phenyl-2-(1-piperidinyl)propane. Drug Metab Dispos 28:905-11 (2000). Read more (PubMed: 10901699) »