2-Phenyl-2-(1-piperidinyl)propane, CYP2B6 inactivator (ab144802)

Overview

  • Product name

    2-Phenyl-2-(1-piperidinyl)propane, CYP2B6 inactivator
  • Description

    Selective CYP2B6 inactivator
  • Alternative names

    • 1-(1-Methyl-1-phenylethyl)piperidine
    • PPP
  • Biological description

    Selective inactivator of CYP2B6 (Ki = 5.6 µM; IC50 = 5.1 µM).

  • CAS Number

    92321-29-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-(1-Methyl-1-phenylethyl)piperidine
  • Molecular weight

    203.32
  • Molecular formula

    C14H21N
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Walsky RL & Obach RS A comparison of 2-phenyl-2-(1-piperidinyl)propane (ppp), 1,1',1''-phosphinothioylidynetrisaziridine (thioTEPA), clopidogrel, and ticlopidine as selective inactivators of human cytochrome P450 2B6. Drug Metab Dispos 35:2053-9 (2007). Read more (PubMed: 17682072) »
  • Chun J  et al. Mechanism-based inactivation of cytochromes P450 2B1 and P450 2B6 by 2-phenyl-2-(1-piperidinyl)propane. Drug Metab Dispos 28:905-11 (2000). Read more (PubMed: 10901699) »

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