Overview

  • Product name

    2',3'-Dideoxyinosine, HIV replication inhibitor
  • Description

    Potent anti-retroviral agent. HIV replication inhibitor.
  • Biological description

    Potent anti-retroviral agent. HIV replication inhibitor. Inhibits reverse transcriptase. Crosses the blood-brain barrier. Active in vivo.
  • Purity

    > 98%
  • CAS Number

    69655-05-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    9-[(2R,5S)-5-(Hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
  • Molecular weight

    236.23
  • Molecular formula

    C10H12N4O3
  • PubChem identifier

    50599
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CC(OC1CO)N2C=NC3=C2NC=NC3=O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Vaccari M  et al. Fatal pancreatitis in simian immunodeficiency virus SIV(mac251)-infected macaques treated with 2',3'-dideoxyinosine and stavudine following cytotoxic-T-lymphocyte-associated antigen 4 and indoleamine 2,3-dioxygenase blockade. J Virol 86:108-13 (2012). Read more (PubMed: 22013040) »
  • Sato K  et al. Influx mechanism of 2',3'-dideoxyinosine and uridine at the blood-placenta barrier. Placenta 30:263-9 (2009). Read more (PubMed: 19135251) »
  • Bishop JB  et al. Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine and dideoxyinosine via maternal dosing, nursing, and direct gavage. Environ Mol Mutagen 43:3-9 (2004). Read more (PubMed: 14743340) »
  • Gibbs JE  et al. Mechanisms by which 2',3'-dideoxyinosine (ddI) crosses the guinea-pig CNS barriers; relevance to HIV therapy. J Neurochem 84:725-34 (2003). Read more (PubMed: 12562517) »

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