Overview

  • Product name

    24(S)-Hydroxycholesterol, Endogenous LXR agonist
  • Description

    Endogenous LXR agonist
  • Biological description

    Endogenous agonist for LXR (EC50 values are 4 μM and 3 μM at LXRα and LXRβ respectively). Involved in cholesterol homeostasis. Induces neuronal cell death by necroptosis, a form of programmed necrosis.
  • Purity

    > 98%
  • CAS Number

    474-73-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Yamanaka K  et al. 24(S)-hydroxycholesterol induces neuronal cell death through necroptosis, a form of programmed necrosis. J Biol Chem 286:24666-73 (2011). Read more (PubMed: 21613228) »
  • Vaya J & Schipper HM Oxysterols, cholesterol homeostasis, and Alzheimer disease. J Neurochem 102:1727-37 (2007). Read more (PubMed: 17573819) »
  • Janowski BA  et al. Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. Proc Natl Acad Sci U S A 96:266-71 (1999). Read more (PubMed: 9874807) »

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