25-Hydroxyvitamin D3 (Calcifediol), metabolite of vitamin D3 (ab142766)

Overview

  • Product name

    25-Hydroxyvitamin D3 (Calcifediol), metabolite of vitamin D3
  • Description

    The major circulating metabolite of vitamin D3 (Cholecalciferol). Calcifediol also has mineralizing properties.
  • Alternative names

    • Calcifediol
  • Biological description

    Principal cholecalciferol (ab143594) metabolite. Downregulates TLR4 and JAK1/STAT3 signaling. Hydroxylates to calcitriol (ab141456) in vivo. Anti-inflammatory effects. Orally active.
  • Purity

    > 98%
  • CAS Number

    19356-17-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-Hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol
  • Molecular weight

    400.64
  • Molecular formula

    C27H44O2
  • PubChem identifier

    5283731
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Li H  et al. 25-hydroxyvitamin D3 ameliorates periodontitis by modulating the expression of inflammation-associated factors in diabetic mice. Steroids 78:115-20 (2013). Read more (PubMed: 23138030) »
  • Wang Q  et al. 25-Hydroxyvitamin D3 attenuates experimental periodontitis through downregulation of TLR4 and JAK1/STAT3 signaling in diabetic mice. J Steroid Biochem Mol Biol 135:43-50 (2013). Read more (PubMed: 23333931) »
  • Dhawan P & Christakos S Novel regulation of 25-hydroxyvitamin D3 24-hydroxylase (24(OH)ase) transcription by glucocorticoids: cooperative effects of the glucocorticoid receptor, C/EBP beta, and the Vitamin D receptor in 24(OH)ase transcription. J Cell Biochem 110:1314-23 (2010). Read more (PubMed: 20564225) »

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