2,7-Dichlorofluorescein, Intracellular fluorescent label (ab146332)

Overview

  • Product name
    2,7-Dichlorofluorescein, Intracellular fluorescent label
  • Description
    Intracellular fluorescent label
  • Biological description
    Intracellular fluorescent label. Zinpyr-1 (ab145349), DCFA (ab145439), DFCA DA (ab145415) and DCFDA N-succinimidyl ester (ab145286) precursor. Marker for cellular oxidative stress.
  • CAS Number
    76-54-0
  • Chemical structure
    Chemical Structure

Properties

  • Excitation
    504nm
  • Emission
    504nm
  • Chemical name
    2',7'-Dichloro-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
  • Molecular weight
    401.20
  • Molecular formula
    C20H10Cl2O5
  • PubChem identifier
    64944
  • Storage instructions
    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in ethanol to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C1=CC=C2C(=C1)C(=O)OC23C4=CC(=C(C=C4OC5=CC(=C(C=C35)Cl)O)O)Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Guo R  et al. Resveratrol suppresses oxidised low-density lipoprotein-induced macrophage apoptosis through inhibition of intracellular reactive oxygen species generation, LOX-1, and the p38 MAPK pathway. Cell Physiol Biochem 34:603-16 (2014). Read more (PubMed: 25116358) »
  • Rota C  et al. Evidence for free radical formation during the oxidation of 2'-7'-dichlorofluorescin to the fluorescent dye 2'-7'-dichlorofluorescein by horseradish peroxidase: possible implications for oxidative stress measurements. Free Radic Biol Med 27:873-81 (1999). Read more (PubMed: 10515592) »
  • Zhu H  et al. Oxidation pathways for the intracellular probe 2',7'-dichlorofluorescein. Arch Toxicol 68:582-7 (1994). Read more (PubMed: 7998826) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"
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