3-BrB-PP1, Akt inhibitor (ab143756)
Key features and details
- Small molecule Akt inhibitor.
- CAS Number: 956025-99-3
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
3-BrB-PP1, Akt inhibitor -
Description
Small molecule Akt inhibitor. -
Alternative names
- 3-[(3-Bromophenyl)methyl]-1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- 4-Amino-1-tert-butyl-3-(3-bromobenzyl)pyrazolo[3,4-d]pyrimidine
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CAS Number
956025-99-3 -
Chemical structure
Properties
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Chemical name
4-Amino-1-tert-butyl-3-(3-bromobenzyl)pyrazolo[3,4-d]pyrimidine -
Molecular weight
360.25 -
Molecular formula
C16H18BrN5 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (9)
ab143756 has been referenced in 9 publications.
- Bhattacharjee R et al. Multiple polarity kinases inhibit phase separation of F-BAR protein Cdc15 and antagonize cytokinetic ring assembly in fission yeast. Elife 12:N/A (2023). PubMed: 36749320
- Prieto-Ruiz F et al. Myosin II regulatory light chain phosphorylation and formin availability modulate cytokinesis upon changes in carbohydrate metabolism. Elife 12:N/A (2023). PubMed: 36825780
- Budden AM et al. Schizosaccharomyces pombe Rtf2 is important for replication fork barrier activity of RTS1 via splicing of Rtf1. Elife 12:N/A (2023). PubMed: 37615341
- Igarashi MG et al. Polarity kinases that phosphorylate F-BAR protein Cdc15 have unique localization patterns during cytokinesis and contributions to preventing tip septation in Schizosaccharomyces pombe. MicroPubl Biol 2023:N/A (2023). PubMed: 37746062
- Zach R & Carr AM Increased expression of Pold does not alter the canonical replication program in vivo. Wellcome Open Res 6:44 (2021). PubMed: 33796794
- Gómez-Gil E et al. Stress-activated MAPK signaling controls fission yeast actomyosin ring integrity by modulating formin For3 levels. Elife 9:N/A (2020). PubMed: 32915139
- Patterson JO et al. Noisy Cell-Size-Correlated Expression of Cyclin B Drives Probabilistic Cell-Size Homeostasis in Fission Yeast. Curr Biol 29:1379-1386.e4 (2019). PubMed: 30955932
- Hörmann A et al. RIOK1 kinase activity is required for cell survival irrespective of MTAP status. Oncotarget 9:28625-28637 (2018). PubMed: 29983885
- Rothe C et al. A checkpoint-independent mechanism delays entry into mitosis after UV irradiation. J Cell Sci 130:4028-4037 (2017). PubMed: 29046339