3-Bromo-7-nitroindazole, nNOS and iNOS inhibitor (ab144716)

Overview

  • Product name

    3-Bromo-7-nitroindazole, nNOS and iNOS inhibitor
  • Description

    nNOS and iNOS inhibitor
  • Biological description

    Neuronal nitric oxide synthase (nNOS) and inducible nitric oxide synthase (iNOS) inhibitor (IC50 = 0.86 μM, 0.17 μM and 0.29 μM for bovine endothelial, rat cerebellar and rat lung NOS enzyme activity respectively). Active in vivo.
  • CAS Number

    74209-34-0
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Zhong HJ  et al. Discovery of a natural product-like iNOS inhibitor by molecular docking with potential neuroprotective effects in vivo. PLoS One 9:e92905 (2014). Read more (PubMed: 24690920) »
  • Hardy P  et al. Developmentally increased cerebrovascular NO in newborn pigs curtails cerebral blood flow autoregulation. Pediatr Res 46:375-82 (1999). Read more (PubMed: 10509356) »
  • Bland-Ward PA & Moore PK 7-Nitro indazole derivatives are potent inhibitors of brain, endothelium and inducible isoforms of nitric oxide synthase. Life Sci 57:PL131-5 (1995). Read more (PubMed: 7544863) »

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