Overview

  • Product name

    3-Deazaneplanocin A
  • Description

    Potent S-adenosylhomocysteine hydrolase (SAHH) and histone methyltransferase (HMT) inhibitor
  • Biological description

    Potent S-adenosylhomocysteine hydrolase (SAHH) and histone methyltransferase (HMT) inhibitor. Anticancer agent. Induces apoptosis in cancer cells but not in normal cells. Active in vivo.
  • Purity

    > 98%
  • CAS Number

    102052-95-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • He S  et al. Inhibition of histone methylation arrests ongoing graft-versus-host disease in mice by selectively inducing apoptosis of alloreactive effector T cells. Blood 119:1274-82 (2012). Read more (PubMed: 22117046) »
  • Kikuchi J  et al. Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells. Lung Cancer 78:138-43 (2012). Read more (PubMed: 22925699) »
  • Hayden A  et al. S-adenosylhomocysteine hydrolase inhibition by 3-deazaneplanocin A analogues induces anti-cancer effects in breast cancer cell lines and synergy with both histone deacetylase and HER2 inhibition. Breast Cancer Res Treat 127:109-19 (2011). Read more (PubMed: 20556507) »
  • Zhou J  et al. The histone methyltransferase inhibitor, DZNep, up-regulates TXNIP, increases ROS production, and targets leukemia cells in AML. Blood 118:2830-9 (2011). Read more (PubMed: 21734239) »
  • Tan J  et al. Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev 21:1050-63 (2007). Read more (PubMed: 17437993) »
  • Glazer RI  et al. 3-Deazaneplanocin: a new and potent inhibitor of S-adenosylhomocysteine hydrolase and its effects on human promyelocytic leukemia cell line HL-60. Biochem Biophys Res Commun 135:688-94 (1986). Read more (PubMed: 3457563) »
See 1 Publication for this product

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