Key features and details
- Lysine methyltransferase EZH2 inhibitor. Highly potent, competitive s-adenosylhomocysteine hydrolase inhibitor.
- CAS Number: 120964-45-6
- Purity: > 98%
- Soluble in water to 10 mM and in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Product name3-Deazaneplanocin A hydrochloride (DZNep), Lysine methyltransferase EZH2 inhibitor
DescriptionLysine methyltransferase EZH2 inhibitor. Highly potent, competitive s-adenosylhomocysteine hydrolase inhibitor.
- DZNep hydrochloride
This product is manufactured by BioVision, an Abcam company and was previously called 2444 3-Deazaneplanocin A hydrochloride. 2444-250 is the same size as the 250 µg size of ab145628.
Chemical name5-(4-Aminoimidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol hydrochloride
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 10 mM and in DMSO to 10 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab145628 has been referenced in 2 publications.
- Duncan EJ et al. Genome Architecture Facilitates Phenotypic Plasticity in the Honeybee (Apis mellifera). Mol Biol Evol 37:1964-1978 (2020). PubMed: 32134461
- Harachi M et al. Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM. Mol Cancer Res 18:1142-1152 (2020). PubMed: 32366675