3-Deazaneplanocin A hydrochloride (DZNep), Lysine methyltransferase EZH2 inhibitor (ab145628)

Overview

  • Product name
    3-Deazaneplanocin A hydrochloride (DZNep), Lysine methyltransferase EZH2 inhibitor
  • Description
    Lysine methyltransferase EZH2 inhibitor. Highly potent, competitive s-adenosylhomocysteine hydrolase inhibitor.
  • Alternative names
    • DZNep hydrochloride
  • Biological description

    Lysine methyltransferase EZH2 inhibitor. Highly potent, competitive s-adenosylhomocysteine hydrolase inhibitor (Ki = 50 pM). Blocks trimethylation of lysine 27 on histone H3 and lysine 20 on histone H4. Induces cancer cell selective apoptosis. Adenosine (ab120498) analog. Selectively increases interferon-α expression in Ebola infected mice. Shows potent antiviral effects in vivo.

  • Purity
    > 98%
  • CAS Number
    120964-45-6
  • Chemical structure
    Chemical Structure

Properties

References

This product has been referenced in:
  • Braun FK  et al. Inhibition of methyltransferases accelerates degradation of cFLIP and sensitizes B-cell lymphoma cells to TRAIL-induced apoptosis. PLoS One 10:e0117994 (2015). Read more (PubMed: 25738497) »
  • Girard N  et al. 3-Deazaneplanocin A (DZNep), an inhibitor of the histone methyltransferase EZH2, induces apoptosis and reduces cell migration in chondrosarcoma cells. PLoS One 9:e98176 (2014). Read more (PubMed: 24852755) »
  • Bray M  et al. 3-deazaneplanocin A induces massively increased interferon-alpha production in Ebola virus-infected mice. Antiviral Res 55:151-9 (2002). Read more (PubMed: 12076759) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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