3-Morpholinosydnonimine hydrochloride (SIN-1 hydrochloride), Vasodilator (ab141525)

Overview

  • Product name

    3-Morpholinosydnonimine hydrochloride (SIN-1 hydrochloride), Vasodilator
  • Description

    Vasodilator. Active metabolite of molsidomine.
  • Alternative names

    • SIN-1
  • Biological description

    Releases NO, superoxide and peroxynitrite under physiological conditions. Potent vasodilator and inhibitor of platelet aggregation. Active metabolite of molsidomine (ab142914). Protective in myocardial ischemia-reperfusion. Orally active.
  • Purity

    > 99%
  • CAS Number

    16142-27-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Sheth CM  et al. Effects of modulating in vivo nitric oxide production on the incidence and severity of PDE4 inhibitor-induced vascular injury in Sprague-Dawley rats. Toxicol Sci 122:7-15 (2011). Read more (PubMed: 21498876) »
  • Priora R  et al. In vitro inhibition of human and rat platelets by NO donors, nitrosoglutathione, sodium nitroprusside and SIN-1, through activation of cGMP-independent pathways. Pharmacol Res 64:289-97 (2011). Read more (PubMed: 21539916) »
  • Gryglewski RJ & Mackiewicz Z Vane's blood-bathed organ technique adapted to examine the endothelial effects of cardiovascular drugs in vivo. Pharmacol Rep 62:462-7 (0). Read more (PubMed: 20631409) »

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