Key features and details
- Selective, irreversible succinic dehydrogenase (complex II) inhibitor.
- CAS Number: 504-88-1
- Purity: > 97%
- Soluble in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
Product name3-Nitropropionic acid, Succinic dehydrogenase (complex II) inhibitor
DescriptionSelective, irreversible succinic dehydrogenase (complex II) inhibitor.
Biological descriptionSelective, irreversible succinic dehydrogenase (complex II) inhibitor. Induces mitochondrial citric acid cycle dysfunction, oxidative stress and cell death. Activates the Keap1-Nrf2-ARE pathway. Inhibits the MAPK and NF-κB pathways. Shows neurotoxic effects in vivo.
Chemical name3-Nitropropionic acid
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in ethanol to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab145589 has not yet been referenced specifically in any publications.