3-O-Methyl-sphingomyelin, neutral sphingomyelinase inhibitor (ab141756)

Overview

  • Product name

    3-O-Methyl-sphingomyelin, neutral sphingomyelinase inhibitor
  • Description

    Cell Permeable neutral sphingomyelinase inhibitor
  • Biological description

    Cell Permeable neutral sphingomyelinase inhibitor (Ki = 37 μM).
  • Purity

    > 98%
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    [(E,2S,3R)-3-Methoxy-2-(octanoylamino)octadec-4-enyl] 2-(trimethylazaniumyl)ethyl phosphate
  • Molecular weight

    604.80
  • Molecular formula

    C32H65N2O6P
  • PubChem identifier

    58311991
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[N+](C)(C)CCOP([O-])(=O)OC[C@H](NC(=O)CCCCCCC)[C@@H](\C=C\CCCCCCCCCCCCC)OC
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Zeng C  et al. Amyloid-beta peptide enhances tumor necrosis factor-alpha-induced iNOS through neutral sphingomyelinase/ceramide pathway in oligodendrocytes. J Neurochem 94:703-12 (2005). Read more (PubMed: 16033420) »
  • Lee JT  et al. Amyloid-beta peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway. J Cell Biol 164:123-31 (2004). Read more (PubMed: 14709545) »
  • Ayasolla K  et al. Inflammatory mediator and beta-amyloid (25-35)-induced ceramide generation and iNOS expression are inhibited by vitamin E. Free Radic Biol Med 37:325-38 (2004). Read more (PubMed: 15223066) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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