3,28-Di-O-(3,3-dimethylglutaryl)betulin, Semisynthetic derivative of betulin (ab144242)

Overview

  • Product name

    3,28-Di-O-(3,3-dimethylglutaryl)betulin, Semisynthetic derivative of betulin
  • Description

    Semisynthetic derivative of betulin
  • Biological description

    Semisynthetic derivative of betulin (ab141471). More potent anti-HIV activity than AZT betulins in vitro.
  • Purity

    > 97%
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Betulin 3,28-(3,3-dimethyl)glutarate
  • Molecular weight

    727.02
  • Molecular formula

    C44H70O8
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C(O)CC(C)(C)CC(=O)OCC35CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@H]2[C@@](C)(CC[C@@H]1[C@]2(C)CC[C@H](OC(=O)CC(C)(C)CC(=O)O)C1(C)C)[C@]4(C)CC3
  • Source

    Synthetic

References

This product has been referenced in:

  • Xiong J  et al. Conjugates of betulin derivatives with AZT as potent anti-HIV agents. Bioorg Med Chem 18:6451-69 (2010). Read more (PubMed: 20673723) »
  • Yogeeswari P & Sriram D Betulinic acid and its derivatives: a review on their biological properties. Curr Med Chem 12:657-66 (2005). Read more (PubMed: 15790304) »
  • Sun IC  et al. Anti-AIDS agents. 34. Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents. J Med Chem 41:4648-57 (1998). Read more (PubMed: 9804704) »

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