3,3'-Diiodo-L-thyronine, Thyroid hormone metabolite (ab145099)

Overview

  • Product name

    3,3'-Diiodo-L-thyronine, Thyroid hormone metabolite
  • Description

    Thyroid hormone metabolite.
  • Alternative names

    • 3,3'-T2
    • 3-[4-(4-Hydroxy-3-iodophenoxy)-3-iodophenyl]-L-alanine
    • O-(4-Hydroxy-3-iodophenyl)-3-iodo-L-tyrosine
    • T2
  • Biological description

    Metabolite of thyroid hormone also known as T2 or 3,3’-T2. Derived enzymatically from triiodothyronine isoforms T3 and reverse T3. Stimulates the activity of cytochrome c oxidase.

  • CAS Number

    4604-41-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-[4-(4-Hydroxy-3-iodophenoxy)-3-iodophenyl]-L-alanine
  • Molecular weight

    525.08
  • Molecular formula

    C15H13I2NO4
  • Storage instructions

    Store at -20°C. Store In the Dark. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overview

    DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Pinna G  et al. 3,3'-Diiodothyronine concentrations in the sera of patients with nonthyroidal illnesses and brain tumors and of healthy subjects during acute stress. J Clin Endocrinol Metab 83:3071-7 (1998). Read more (PubMed: 9745405) »
  • Goglia F  et al. Interaction of diiodothyronines with isolated cytochrome c oxidase. FEBS Lett 346:295-8 (1994). Read more (PubMed: 8013649) »

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