Overview

  • Product name

    3,5-dimethyl PIT-1, PIP3/protein binding inhibitor
  • Description

    PIP3/protein binding inhibitor
  • Biological description

    PIP3/protein binding inhibitor. Dimethyl analog of PIT-1 (ab120885) that is designed for more favorable solubility in vivo. Specifically disrupts PIP3/Akt PH domain binding (IC50 = 27 μM); suppresses PI3K-PDK1-Akt-dependent phosphorylation. Reduces cell viability and induces apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 36 μM).
  • Purity

    > 98%
  • CAS Number

    701947-53-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Miao B  et al. Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains. Proc Natl Acad Sci U S A 107:20126-31 (2010). Read more (PubMed: 21041639) »
  • Vivanco I & Sawyers CL The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2:489-501 (2002). Read more (PubMed: 12094235) »

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