3H-1,2-Dithiole-3-thione, antioxidant (ab141925)
- Datasheet
- References
Overview
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Product name
3H-1,2-Dithiole-3-thione, antioxidant -
Description
Potent antioxidant -
Biological description
Potent antioxidant. Increases catalase and MnSoD in vivo. Blocks LPS-mediated induction of hepatic iNOS in vivo. Chemoprotective agent. Orally active. Active in vitro and in vivo. -
Purity
> 98% -
CAS Number
534-25-8 -
Chemical structure
Properties
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Chemical name
Dithiole-3-thione -
Molecular weight
134.25 -
Molecular formula
C3H2S3 -
PubChem identifier
68296 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CSSC1=S -
Source
Synthetic
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Research areas
References
This product has been referenced in:
- Pazdro R & Burgess JR The antioxidant 3H-1,2-dithiole-3-thione potentiates advanced glycation end-product-induced oxidative stress in SH-SY5Y cells. Exp Diabetes Res 2012:137607 (2012). Read more (PubMed: 22675339) »
- Karuri AR et al. 3H-1,2-dithiole-3-thione targets nuclear factor kappaB to block expression of inducible nitric-oxide synthase, prevents hypotension, and improves survival in endotoxemic rats. J Pharmacol Exp Ther 317:61-7 (2006). Read more (PubMed: 16371450) »
- Otieno MA et al. Chemoprotective 3H-1,2-dithiole-3-thione induces antioxidant genes in vivo. Free Radic Biol Med 28:944-52 (2000). Read more (PubMed: 10802226) »
