3H-1,2-Dithiole-3-thione, antioxidant (ab141925)
Key features and details
- Potent antioxidant
- CAS Number: 534-25-8
- Purity: > 98%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
3H-1,2-Dithiole-3-thione, antioxidant -
Description
Potent antioxidant -
Biological description
Potent antioxidant. Increases catalase and MnSoD in vivo. Blocks LPS-mediated induction of hepatic iNOS in vivo. Chemoprotective agent. Orally active. Active in vitro and in vivo. -
Purity
> 98% -
CAS Number
534-25-8 -
Chemical structure
Properties
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Chemical name
Dithiole-3-thione -
Molecular weight
134.25 -
Molecular formula
C3H2S3 -
PubChem identifier
68296 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CSSC1=S -
Source
Synthetic
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Research areas
Images
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab141925 has been referenced in 2 publications.
- Wu TT et al. 3H-1,2-Dithiole-3-Thione Protects Lens Epithelial Cells against Fructose-Induced Epithelial-Mesenchymal Transition via Activation of AMPK to Eliminate AKR1B1-Induced Oxidative Stress in Diabetes Mellitus. Antioxidants (Basel) 10:N/A (2021). PubMed: 34356319
- Wang J et al. Loss of Oxidation Resistance 1, OXR1, Is Associated with an Autosomal-Recessive Neurological Disease with Cerebellar Atrophy and Lysosomal Dysfunction. Am J Hum Genet 105:1237-1253 (2019). PubMed: 31785787