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3H-1,2-Dithiole-3-thione, antioxidant (ab141925)

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Chemical Structure - 3H-1,2-Dithiole-3-thione, antioxidant (ab141925)

    Key features and details

    • Potent antioxidant
    • CAS Number: 534-25-8
    • Purity: > 98%
    • Soluble in DMSO to 50 mM
    • Form / State: Solid
    • Source: Synthetic

    Overview

    • Product name

      3H-1,2-Dithiole-3-thione, antioxidant

    • Description

      Potent antioxidant

    • Biological description

      Potent antioxidant. Increases catalase and MnSoD in vivo. Blocks LPS-mediated induction of hepatic iNOS in vivo. Chemoprotective agent. Orally active. Active in vitro and in vivo.

    • Purity

      > 98%

    • CAS Number

      534-25-8

    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      Dithiole-3-thione

    • Molecular weight

      134.25

    • Molecular formula

      C3H2S3

    • PubChem identifier

      68296

    • Storage instructions

      Store at Room Temperature. The product can be stored for up to 12 months.

    • Solubility overview

      Soluble in DMSO to 50 mM

    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      C1=CSSC1=S

    • Source

      Synthetic

    • Research areas

    Images

    • Chemical Structure - 3H-1,2-Dithiole-3-thione, antioxidant (ab141925)
      Chemical Structure - 3H-1,2-Dithiole-3-thione, antioxidant (ab141925)
      2D chemical structure image of ab141925, 3H-1,2-Dithiole-3-thione, antioxidant

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (2)

    Publishing research using ab141925? Please let us know so that we can cite the reference in this datasheet.

    ab141925 has been referenced in 2 publications.

    • Wu TT  et al. 3H-1,2-Dithiole-3-Thione Protects Lens Epithelial Cells against Fructose-Induced Epithelial-Mesenchymal Transition via Activation of AMPK to Eliminate AKR1B1-Induced Oxidative Stress in Diabetes Mellitus. Antioxidants (Basel) 10:N/A (2021). PubMed: 34356319
    • Wang J  et al. Loss of Oxidation Resistance 1, OXR1, Is Associated with an Autosomal-Recessive Neurological Disease with Cerebellar Atrophy and Lysosomal Dysfunction. Am J Hum Genet 105:1237-1253 (2019). PubMed: 31785787

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