3MB-PP1, tyrosine kinase inhibitor (ab143754)

Overview

  • Product name

    3MB-PP1, tyrosine kinase inhibitor
  • Description

    Specific tyrosine kinase inhibitor.
  • Alternative names

    • 1-(1,1-Dimethylethyl)-3-[(3-methylphenyl)methyl]-1H-Pyrazolo[3,4-d]pyrimidin-4-
    • 3-MB-PP1
    • 4-Amino-1-tert-butyl-3-(3-methylbenzyl)pyrazolo[3,4-d]pyrimidine
  • Biological description

    Uniquely specific bulky tyrosine kinase inhibitor which targets a mutant kinase version with an enlarged catalytic pocket while not interfering with wild-type Plk1.

  • CAS Number

    956025-83-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-Amino-1-tert-butyl-3-(3-methylbenzyl)pyrazolo[3,4-d]pyrimidine
  • Molecular weight

    295.38
  • Molecular formula

    C17H21N5
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Klammer M  et al. Identification of significant features by the Global Mean Rank test. PLoS One 9:e104504 (2014). Read more (PubMed: 25119995) »
  • Oppermann FS  et al. Combination of chemical genetics and phosphoproteomics for kinase signaling analysis enables confident identification of cellular downstream targets. Mol Cell Proteomics 11:O111.012351 (2012). Read more (PubMed: 22199227) »

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