4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid sodium salt, fluorescent marker (ab144879)

Overview

  • Product name

    4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid sodium salt, fluorescent marker
  • Description

    Specific, reversible fluorescent marker for the labeling of the outer components of the plasma membrane. Inactivates Na,K-ATPase.
  • Alternative names

    • SITS
  • Biological description

    Specific, reversible fluorescent marker for the labeling of the outer components of the plasma membrane. Also inactivates Na,K-ATPase, by covalent modification of a specific Lys residue.

  • CAS Number

    51023-76-8
  • Chemical structure

    Chemical Structure

Properties

  • Excitation

    336nm
  • Emission

    436nm
  • Chemical name

    Disodium 4-acetamido-4'-isothiocyanatostilbene-2,2'-disulfonate
  • Molecular weight

    498.52
  • Molecular formula

    C17H12N2Na2O7S3
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    DMSO, water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Ma W  et al. Pharmacological characterization of pannexin-1 currents expressed in mammalian cells. J Pharmacol Exp Ther 328:409-18 (2009). Read more (PubMed: 19023039) »
  • Pedemonte CH  et al. Inactivation of the Na,K-ATPase by modification of Lys-501 with 4-acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid (SITS). FEBS Lett 314:97-100 (1992). Read more (PubMed: 1333419) »
  • Cardin AD  et al. Stilbene disulfonic acids. CD4 antagonists that block human immunodeficiency virus type-1 growth at multiple stages of the virus life cycle. J Biol Chem 266:13355-63 (1991). Read more (PubMed: 2071607) »
  • MADDY AH A FLUORESCENT LABEL FOR THE OUTER COMPONENTS OF THE PLASMA MEMBRANE. Biochim Biophys Acta 88:390-9 (1964). Read more (PubMed: 14253225) »

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