4-alpha-Phorbol-12-myristate-13-acetate, Negative control (ab143538)

Overview

  • Product name

    4-alpha-Phorbol-12-myristate-13-acetate, Negative control
  • Description

    Negative control for PMA
  • Biological description

    Negative control for PMA. Opposes effects of PMA on PKC. Cell-permeable.
  • Purity

    > 98%
  • CAS Number

    63597-44-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(Acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl ester tetradecanoic acid
  • Molecular weight

    616.83
  • Molecular formula

    C36H56O8
  • PubChem identifier

    122634
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCCCCCCCCCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)C)O)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Jackson A  et al. Opposing effects of phorbol-12-myristate-13-acetate, an activator of protein kinase C, on the signaling of structurally related human dopamine D1 and D5 receptors. J Neurochem 95:1387-400 (2005). Read more (PubMed: 16313517) »
  • González MI  et al. Phorbol myristate acetate-dependent interaction of protein kinase Calpha and the neuronal glutamate transporter EAAC1. J Neurosci 23:5589-93 (2003). Read more (PubMed: 12843260) »
  • Mwimbi XK  et al. 4alpha-Phorbol negates the inhibitory effects of phorbol-12-myristate-13-acetate on human cilia and alters the phosphorylation of PKC. FEBS Lett 530:31-6 (2002). Read more (PubMed: 12387861) »
See 1 Publication for this product

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