Key features and details
- Selective PARP-1 inhibitor
- CAS Number: 1742-95-6
- Purity: > 98%
- Soluble in DMSO to 25 mM (with warming)
- Form / State: Solid
- Source: Synthetic
Product name4-Aminonaphthalimide, PARP-1 inhibitor
DescriptionSelective PARP-1 inhibitor
Biological descriptionSelective PARP-1 inhibitor (IC50 = 0.18 μM). Sensitizes cells to chemical and radiation induced cytotoxicity. Protective against ischemia-reperfusion injury. Active in vitro and in vivo. Highly cell-permeable.
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 25 mM (with warming)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Epigenetics and Nuclear Signaling
- DNA / RNA
- DNA Damage & Repair
- DNA Damage Response
- DNA Damage Recognition
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab144620 has not yet been referenced specifically in any publications.