4-Aminonaphthalimide, PARP-1 inhibitor (ab144620)

Overview

  • Product name

    4-Aminonaphthalimide, PARP-1 inhibitor
  • Description

    Selective PARP-1 inhibitor
  • Biological description

    Selective PARP-1 inhibitor (IC50 = 0.18 μM). Sensitizes cells to chemical and radiation induced cytotoxicity. Protective against ischemia-reperfusion injury. Active in vitro and in vivo. Highly cell-permeable.
  • Purity

    > 98%
  • CAS Number

    1742-95-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-Amino-1,8-naphthalimide
  • Molecular weight

    212.20
  • Molecular formula

    C12H8N2O2
  • PubChem identifier

    1720
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM (with warming)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC2=C(C=CC3=C2C(=C1)C(=O)NC3=O)N
  • Source

    Synthetic

References

This product has been referenced in:

  • Jiang X  et al. [Effect of PARP-1 inhibitor 4-amino-1 ,8-naphthalimide on the on the sensitivity of adriamycin]. Wei Sheng Yan Jiu 41:173-9 (2012). Read more (PubMed: 22611920) »
  • Kabra DG  et al. Neuroprotective effect of 4-amino-1,8-napthalimide, a poly(ADP ribose) polymerase inhibitor in middle cerebral artery occlusion-induced focal cerebral ischemia in rat. Brain Res Bull 62:425-33 (2004). Read more (PubMed: 15168908) »
  • Schlicker A  et al. 4-Amino-1,8-naphthalimide: a novel inhibitor of poly(ADP-ribose) polymerase and radiation sensitizer. Int J Radiat Biol 75:91-100 (1999). Read more (PubMed: 9972795) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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