Overview

  • Product name

    4-Aminopyridine (4-AP), K+ channel blocker
  • Description

    K+ channel blocker
  • Alternative names

    • 4-AP
  • Biological description

    Potassium channel blocker. Blocks Kv channels. Convulsant, and useful tool to model epileptiform activity in vitro.
  • Purity

    > 99%
  • CAS Number

    504-24-5
  • Chemical structure

    Chemical Structure

Properties

Images

  • 4-AP-induced LFPs provoke AP firing from SST-interneurons. Representative images of GCaMP3 signal in a visual field containing several SST interneurons before (left) and during (right) LFPP-CA3/DG (induced with 4-AP).

    Grosser S et al., PloS one., 9(1): e86250. Fig 3A.; doi: 10.1371/journal.pone.0086250

References

This product has been referenced in:

  • Yazdi HH  et al. The role of small-conductance Ca2+-activated K+ channels in the modulation of 4-aminopyridine-induced burst firing in rat cerebellar Purkinje cells. Brain Res 1156:59-66 (2007). Read more (PubMed: 17493598) »
  • Jenkinson DH Potassium channels--multiplicity and challenges. Br J Pharmacol 147 Suppl 1:S63-71 (2006). Read more (PubMed: 16402122) »
  • Kubo Y  et al. International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. Pharmacol Rev 57:509-26 (2005). Read more (PubMed: 16382105) »
See all 9 Publications for this product

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