4-Aminopyridine (4-AP), K+ channel blocker (ab120122)
- Datasheet
- References (9)
Overview
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Product name
4-Aminopyridine (4-AP), K+ channel blocker -
Description
K+ channel blocker -
Alternative names
- 4-AP
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Biological description
Potassium channel blocker. Blocks Kv channels. Convulsant, and useful tool to model epileptiform activity in vitro. -
Purity
> 99% -
CAS Number
504-24-5 -
Chemical structure
Properties
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Chemical name
4-Aminopyridine -
Molecular weight
94.12 -
Molecular formula
C5H6N2 -
PubChem identifier
1727 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Nc1ccncc1 -
Source
Synthetic
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Research areas
Images
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Immunocytochemistry/ Immunofluorescence - 4-Aminopyridine (4-AP), K+ channel blocker (ab120122)Image from Grosser S et al., PloS one., 9(1): e86250. Fig 3A.; doi: 10.1371/journal.pone.0086250 Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/4-AP-induced LFPs provoke AP firing from SST-interneurons. Representative images of GCaMP3 signal in a visual field containing several SST interneurons before (left) and during (right) LFPP-CA3/DG (induced with 4-AP).
Grosser S et al., PloS one., 9(1): e86250. Fig 3A.; doi: 10.1371/journal.pone.0086250
References
This product has been referenced in:
- Yazdi HH et al. The role of small-conductance Ca2+-activated K+ channels in the modulation of 4-aminopyridine-induced burst firing in rat cerebellar Purkinje cells. Brain Res 1156:59-66 (2007). Read more (PubMed: 17493598) »
- Jenkinson DH Potassium channels--multiplicity and challenges. Br J Pharmacol 147 Suppl 1:S63-71 (2006). Read more (PubMed: 16402122) »
- Kubo Y et al. International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. Pharmacol Rev 57:509-26 (2005). Read more (PubMed: 16382105) »
